RESEARCH REBEL • EVIDENCE DOSSIER

Elamipretide / SS-31

HUMAN RANDOMIZED TRIALS

A mitochondria-targeting tetrapeptide studied in randomized human trials. Outcomes vary by population and endpoint.

WHAT WE KNOW
  • A randomized study in 39 older adults reported an acute improvement in a mitochondrial energetic measure.
  • MMPOWER-3 was a phase 3 randomized placebo-controlled trial in primary mitochondrial myopathy.
WHAT WE DON'T KNOW
  • Generalizability to healthy optimization use.
  • Whether community protocols reproduce clinical exposure or outcomes.
PUBLISHED PROTOCOL EVIDENCE

Study parameter ≠ universal protocol.

Clinical-trial amounts, routes and durations are displayed only as study parameters attached to the original trial.

Numerical study entries carry:PopulationRouteFormulationAmountFrequencyDurationEndpointSource
COMMUNITY EVIDENCE

Document it. Don't upgrade it.

Community reports often focus on energy and exercise recovery; these are subjective and should include concurrent interventions.

Reported amount/rangeRouteFrequencyDurationGoalReported positivesReported negativesConcurrent compoundsSource + N
COMMUNITY-REPORTED • NOT CLINICALLY VALIDATED